A cellular revolution begins here: NAD+ therapy explained

Imagine if you could recharge your body’s cellular engines, heal damaged DNA, and reclaim lost energy, all in one medically supervised treatment. That’s precisely what NAD+ therapy at Dr Yusra Clinic offers: a science-backed way to restore vitality where it matters most.

Right up front, yes: NAD+ (nicotinamide adenine dinucleotide) fuels your mitochondria and activates DNA‑repair enzymes, and declining levels with age contribute to fatigue, cognitive decline, and skin ageing. In other words, restoring NAD+ supports cellular repair, energy, mental clarity, and radiance.

What does NAD+ do?

NAD+ is a pivotal coenzyme present in every living cell, essential for redox reactions that power glycolysis, the TCA cycle and oxidative phosphorylation, ultimately generating ATP, the energy currency of life.

But its function extends far beyond energy production: NAD+ is the substrate for sirtuins (like SIRT1) and PARP enzymes, which govern DNA repair, chromatin integrity, inflammation control, and gene expression regulation.

Without sufficient NAD+, these enzyme systems falter, leading to reduced DNA repair capacity and mitochondrial dysfunction, which manifest as visible ageing and systemic decline.

Do NAD+ Supplements Actually Work?

It’s a fair question, and one that’s sparked growing buzz in the wellness and medical community. The short answer? We’re seeing promising signs, especially when it comes to boosting energy, focus, and healthy ageing.

NAD+ supplements don’t contain NAD+ itself but instead deliver precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside). These are converted by the body into NAD+, helping replenish the levels that naturally decline with age.

So, what does the science say?

🔬 In lab studies, older mice given these supplements regained youthful energy, improved their muscle strength, repaired damaged DNA, and even lived longer.

👩‍⚕️ In early human trials, adults taking NMN or NR have reported enhanced energy levels, better metabolism, sharper focus, and improved overall wellbeing. There’s also some evidence of improved insulin sensitivity and cardiovascular markers.

🧪 However, while the early research is encouraging, larger human trials are still ongoing. What we do know is that NAD+ therapy is safe, well-tolerated, and already helping many people feel more like themselves again.

At Dr Yusra Clinic, we offer clinician-supervised NAD+ protocols, combining medical oversight with personalised advice to help you get the most out of your treatment, whether you’re taking oral supplements or receiving injectable infusions.

Is NAD+ just vitamin B3?

Technically, NAD+ derives from forms of vitamin B3, but it is far more than a typical nutrient. Nicotinic acid and nicotinamide can enter cellular salvage pathways to form NAD+, but the more modern supplements NR and NMN are streamlined precursors with enhanced bioavailability.

NMN is metabolised via intracellular enzymes (e.g. CD73, ENT transporters) into NAD+, which then fuels sirtuins and repair systems. Though related to vitamin B3, NAD+ is distinct, serving as a central hub in cellular metabolism and gene regulation, not merely a dietary cofactor.

How can I raise my NAD levels naturally?

While supplementation and therapy offer potent results, lifestyle strategies can support your endogenous NAD+ production:

• Nutrition: Foods high in B3, such as whole grains, lean proteins, mushrooms, leafy greens, eggs and dairy, support the NAD salvage pathway.
  
• Exercise and fasting: Intermittent fasting or calorie restriction can stimulate NAD+ pathways; regular high-intensity interval training (HIIT) helps too.
  
• Stress management and inflammation control: Chronic inflammation accelerates NAD+ depletion via CD38 and PARPs; antioxidant-rich diet and adequate sleep help preserve NAD+.

The Dr Yusra Clinic approach to NAD+ therapy & cellular repair

At Dr Yusra Clinic in Manchester, NAD+ therapy is offered via carefully dosed intravenous infusions, supervised by medical professionals, and tailored for individual wellness goals. This ensures maximum bioavailability, bypassing digestive degradation common in oral supplements.

Patients frequently report:

• Renewed daytime energy and mental clarity
  
• Improved skin texture and glow
  
• Reduced recovery time post-exercise
  
• Greater resilience to fatigue and stress
  

By harnessing the cellular mechanisms of DNA repair, mitochondrial revitalisation and anti-inflammatory modulation, NAD+ therapy acts as a cellular reboot, helping patients age gracefully and proactively.

Injectables vs oral: Which is best?

Injectable NAD+ offers near‑complete bioavailability and immediate uptake, making it ideal for recovery, burnout recovery or rapid rejuvenation.

Oral precursors (NR, NMN) provide steady increases over time, but bioavailability varies and efficacy remains dose‑dependent. Injection protocols at Dr Yusra Clinic are personalised, typically administered over a 4-12 week intensive span followed by maintenance phases, depending on individual goals.

Safety, side effects & suitability

Clinical reports and anecdotal feedback suggest NAD+ therapy is generally well tolerated. Mild side effects may include nausea, headaches, flushing or dizziness, but these are usually transient and manageable by adjusting infusion rate.

However, NOT suitable for individuals with:

• Active cancer (due to cell metabolism concerns)
  
• Severe liver or kidney disease
  
• Uncontrolled cardiovascular conditions
  
• Pregnant or breastfeeding women
  All therapies are delivered only after thorough medical consultation to ensure suitability.
  

Why Dr Yusra Clinic’s NAD+ therapy is a wise choice

• Utilises award‑winning expertise, Dr Yusra Al‑Mukhtar, Best Medical Aesthetic Practitioner in the UK and globally, inducted into the Aesthetic Medicine Wall of Fame
  
• One of only leading clinics in the North of England recognised three times for Best Aesthetic Clinic & Best Clinical Team
  
• Treatment delivered with science‑driven protocols in a boutique, patient‑centred environment
  

Whether you’re seeking improvement in energy, cognitive clarity, skin regeneration, or metabolic support, NAD+ therapy at Dr Yusra Clinic offers a premium, evidence‑aligned pathway to cellular rejuvenation.

If you are searching for NAD+ therapy near me, look to Dr Yusra Clinic in Manchester for a clinician‑led, medically supervised restoration of NAD+ levels that supports graceful ageing and internal health.

Ready to Reset Your Cells?

If you’re feeling low in energy, struggling with brain fog, or simply seeking a proactive, medical approach to ageing well, NAD+ therapy at Dr Yusra Clinic could be your next step. This advanced treatment supports cellular repair, DNA protection, and energy regeneration, restoring function from the inside out.

Our award-winning medical team offers NAD+ therapy at our leading clinics in Manchester, London, and Liverpool, with personalised treatment plans built around your health, lifestyle, and goals.

Book a consultation at your nearest Dr Yusra Clinic and let us help you optimise your cellular health with expert-led NAD+ therapy.

👉 Get started here and take the first step towards long-lasting energy, clarity, and wellness.

FAQs

1. What does NAD+ do for aging and energy?

NAD+ fuels mitochondrial energy production and activates DNA‑repair and sirtuin systems; its decline contributes to fatigue, cognitive slowdown, and visible ageing.

2. Are NAD+ supplements effective for cellular repair?

Early animal studies and limited human trials suggest NMN and NR improve metabolic markers, muscle function, and aerobic capacity, but large‑scale human data is still emerging.

3. Is NAD+ the same as vitamin B3?

No, while NAD+ originates from B3 precursors, it is a distinct coenzyme central to energy cycles and gene regulation, far beyond a simple vitamin.

4. How does NAD+ therapy at Dr Yusra Clinic work?

We offer medically supervised IV infusions of NAD+ for maximised absorption, personalised protocol based on your goals, followed by optional maintenance phase for sustained results.

5. What are the risks and who shouldn’t take NAD+ therapy?

Most clients tolerate therapy well. Mild side effects like nausea or headache may occur. Contraindications include active cancer, severe liver/kidney issues, unstable heart conditions, and pregnancy, it’s only given after medical evaluation.

Award‑Winning Aesthetic Excellence
Dr. Yusra Al‑Mukhtar has been recognised as the Best Medical Aesthetic Practitioner of the Year for three consecutive years; a prestigious honour awarded based on exceptional clinical expertise, patient outcomes, safety standards, and dedication to aesthetic excellence. She is also the first medical practitioner to be inducted into the Aesthetic Medicine Wall of Fame, a landmark achievement that reflects her leadership and influence in the field of aesthetic medicine in the UK and internationally.

At Dr Yusra Clinic, we are equally proud to be named Best Aesthetic Clinic in the North of England and Best Clinical Team, both three times, acknowledging our commitment to the highest standards of patient care, medical ethics, and outstanding treatment results. These industry-leading awards recognise our team’s collective dedication to delivering safe, personalised, and science-led aesthetic treatments that help our patients look and feel their best.

If you are searching for an award‑winning aesthetic clinic known for natural results, advanced techniques, and patient‑centred care, you are in expert hands with Dr Yusra Clinic.

Olivia

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